Which syndrome is associated with parathyroid hyperplasia, pancreatic lesions, and pituitary adenomas?

The correct answer is associated with Multiple Endocrine Neoplasia Type I (MEN I), also known as Wermer's syndrome. This genetic condition is characterized by a triad of tumors primarily affecting the parathyroid glands, pancreas, and pituitary gland.

In MEN I, parathyroid hyperplasia leads to hyperparathyroidism, which is a common feature of the syndrome. This results in elevated levels of calcium in the blood, causing various symptoms such as kidney stones, bone pain, and abdominal discomfort. Pancreatic lesions, which may include neuroendocrine tumors (such as insulinomas or gastrinomas), are also common and can result in hormonal imbalances. Pituitary adenomas are typically benign tumors of the pituitary gland that can lead to hypersecretion of hormones, which can have systemic effects on the body.

The combination of these three types of neoplasms—parathyroid, pancreatic, and pituitary—provides a clear clinical picture that is consistent with MEN I. Understanding these associations is crucial for diagnosis and management of individuals with this syndrome.

In contrast, MEN IIb primarily involves medullary thyroid carcinoma, pheochromocytomas, and mucosal neuromas but does not typically feature