Which lung cancer is associated with a P53 mutation and secretes a parathyroid-like hormone?

The correct answer is that Squamous Cell Carcinoma of the Lung is associated with a P53 mutation and can secrete a parathyroid-like hormone (PTHrP).

Squamous Cell Carcinoma often arises in the central bronchi and is linked to smoking. One of its defining characteristics is the frequent occurrence of genetic mutations, particularly in the tumor suppressor gene P53. This mutation disrupts the normal regulation of the cell cycle, allowing aberrant cell proliferation, which is a hallmark of cancer.

Additionally, many squamous cell carcinomas can produce parathyroid hormone-related peptide (PTHrP). This is particularly significant because PTHrP can lead to hypercalcemia, a common paraneoplastic syndrome associated with this type of lung cancer. Hypercalcemia occurs when the levels of calcium in the blood become elevated due to the secretion of PTHrP, mimicking the action of parathyroid hormone.

Other types of lung cancer, like small cell lung cancer, while aggressive and also associated with various paraneoplastic syndromes, primarily produce other biomarkers and mutations, such as amplification of the MYC oncogene, rather than P53 mutations in the same manner. Bronchial carcinoid tumors