Which deficiency leads to Pellagra?

Pellagra is specifically caused by a deficiency in niacin, which is also known as Vitamin B3. This vitamin plays a critical role in energy metabolism and is essential for the synthesis of certain coenzymes that are vital for the body's metabolic processes. When there is an inadequate intake of niacin or tryptophan (which the body can convert into niacin), the individual can develop Pellagra, which is characterized by the classic triad of symptoms: dermatitis, diarrhea, and dementia.

Understanding this, it is clear that other vitamin deficiencies do not lead to Pellagra. For instance, Vitamin A deficiency can lead to vision problems and skin issues, while Vitamin B2 (riboflavin) deficiency might affect skin and mucosal health, and Vitamin B12 deficiency is associated with anemia and neurological issues. However, none of these deficiencies cause the specific symptoms and conditions associated with Pellagra, making niacin deficiency the correct answer in this context.