Where are vegetations associated with Libman-Sacks Endocarditis primarily located?

Vegetations associated with Libman-Sacks Endocarditis are primarily located on both surfaces of the valve leaflets. This depiction of extension is distinct because Libman-Sacks Endocarditis is often linked to systemic lupus erythematosus (SLE), where the vegetations are characterized by their non-bacterial nature and can appear as small, sterile lesions.

These vegetations tend to form on both the atrial and ventricular sides of the valve leaflets, reflecting a more diffuse involvement, which can lead to a greater impact on the heart's valves compared to other types of endocarditis. The presence of these vegetations on both surfaces can contribute to valve dysfunction and can be associated with other cardiac abnormalities seen in patients with SLE.

In other types of endocarditis, vegetations may be more localized to one side or the other based on the infective agent and the nature of the pathology. However, in Libman-Sacks Endocarditis, the widespread, bilateral nature of the vegetations is a hallmark characteristic.