What type of cells are prominent in oncocytomas?

Oncocytomas are characterized by the presence of large eosinophilic cells, which are specifically known for their abundance of mitochondria. These cells have a distinctive appearance due to their granular, eosinophilic (pink-staining) cytoplasm when viewed under a microscope. The term "oncocyte" refers to these cells, which arise due to an increase in mitochondrial content, often linked to cellular stress or reactive changes.

In oncocytomas, particularly those found in glands such as the salivary glands or kidneys, these eosinophilic cells are the predominant cell type. Their presence is a key indicator of this tumor subtype, reflecting the tumor's origin and cellular composition.

Other cell types, such as mucosal cells, giant cells, or fibroblasts, do not characterize oncocytomas in the same way. Mucosal cells are typically found in epithelial tissues and would not be prominent in this tumor type. Giant cells are associated with granulomatous inflammation and are not a feature of oncocytomas. Fibroblasts are connective tissue cells that play a role in wound healing but are not inherent to oncocytomas. Thus, the prominence of large eosinophilic cells is what defines oncocytomas and distinguishes