What percentage of hepatocellular carcinomas are classified as Fibrolamellar carcinoma?

Fibrolamellar carcinoma is a rare variant of hepatocellular carcinoma that is distinguished by its unique histological features and is typically found in younger patients without significant liver disease. This carcinoma accounts for approximately 5% of all hepatocellular carcinoma cases.

Understanding the prevalence of fibrolamellar carcinoma within the broader category of hepatocellular carcinomas highlights its unusual nature and differentiates it from more common subtypes. It emphasizes the importance of recognizing this variant, especially in young patients presenting with liver tumors, as it can have different prognostic implications and treatment approaches compared to more common types of liver cancer. This specific statistic about fibrolamellar carcinoma can also be valuable for pathology assistants when evaluating liver specimens and providing accurate diagnoses.