What is the origin cell type for a meningioma?

Meningiomas originate from arachnoidal cells, which are the cells that make up the arachnoid mater, one of the three layers of protective membranes (meninges) surrounding the brain and spinal cord. These tumors are typically benign and can arise in various locations, often attached to the dura mater. The relationship between meningiomas and arachnoidal cells is well established in pathology, as these tumors display features consistent with the normal function and histological appearance of arachnoid cells.

In contrast, other cell types listed, such as neurons, microglia, and endothelial cells, do not give rise to meningiomas. Neurons are the primary functional cells of the nervous system, while microglia are the resident immune cells of the central nervous system. Endothelial cells line blood vessels and do not form meningiomas. Therefore, the correct identification of the origin cell type is fundamental in understanding the pathology and behavior of these tumors.