What is the genetic inheritance pattern of Gardner Syndrome?

Gardner Syndrome is characterized by the presence of multiple benign tumors, particularly in the gastrointestinal tract, along with a predisposition to colorectal cancer. The genetic inheritance pattern of Gardner Syndrome is classified as autosomal dominant. This means that only one copy of the mutated gene inherited from either parent is sufficient to manifest the condition in an individual.

The syndrome is caused by mutations in the APC (Adenomatous Polyposis Coli) gene, which is located on chromosome 5. Because it follows an autosomal dominant pattern, there is a 50% chance of passing the mutation to offspring if one parent is affected by the syndrome. Individuals who inherit the mutation have a significant risk of developing numerous adenomatous polyps, which can lead to cancer if not managed appropriately.

Understanding that Gardner Syndrome is autosomal dominant is crucial for genetic counseling and risk assessment for families affected by this condition, as well as for implementing appropriate surveillance measures to manage the risk of colorectal cancer.