What is a primary cause of Angiosarcoma (hemangiosarcoma)?

Angiosarcoma, also known as hemangiosarcoma, is a rare and aggressive malignant tumor that arises from endothelial cells lining blood vessels. One of the primary risk factors associated with angiosarcoma is exposure to certain environmental toxins. Specifically, exposure to polyvinyl chloride (PVC), a type of plastic, and arsenic has been heavily implicated in its development.

PVC is often used in construction and various industrial products. Over time, individuals who work with or are exposed to high levels of PVC have been found to have an increased risk of developing angiosarcoma, particularly in the liver. Arsenic, a toxic metalloid found in some industrial processes and contaminated water supplies, has also been linked to an increased incidence of several types of cancer, including angiosarcoma. Both polyvinyl chloride and arsenic have carcinogenic properties which can lead to mutations in cells that over time may result in the development of tumors such as angiosarcoma.

While previous radiation therapy is a known risk factor for various cancers, including sarcomas, it is not as specifically associated with angiosarcoma as the toxic exposures are. Similarly, while genetic predispositions can play a role in many cancers, particularly with familial syndromes