What is a feature of Granulosa Cell Tumors, which are relevant in young girls?

Granulosa Cell Tumors are a type of sex-cord stromal tumor that primarily arise in the ovaries and can be particularly relevant in young girls and women. A defining feature of these tumors is the presence of Call-Exner bodies, which are structures that resemble immature Graafian follicles and consist of small round structures filled with eosinophilic material. These bodies indicate the presence of abnormal follicle-like structures, further emphasizing the tumor's hormonal activity and its potential to secrete estrogen.

Their estrogenic influence is significant, particularly in young girls, because it can lead to precocious puberty or other symptoms related to estrogen excess. This hormonal activity is reflective of the tumor’s origin from the sex-cord cells of the ovary.

Call-Exner bodies serve as a histological hallmark for identifying Granulosa Cell Tumors during microscopic examination of tissue samples. This feature not only assists in diagnosis but also helps in predicting the tumor’s behavior and guiding treatment options.