What is a common systemic effect of Small Cell Lung Cancer?

Small Cell Lung Cancer (SCLC) is known for producing ectopic hormones and can lead to a variety of paraneoplastic syndromes. One of the most notable systemic effects associated with SCLC is the development of Cushing's syndrome. This occurs because SCLC can produce adrenocorticotropic hormone (ACTH) or corticotropin-releasing hormone (CRH), which stimulate the adrenal glands to produce cortisol. Excess cortisol in the body results in the characteristic symptoms of Cushing’s syndrome, such as weight gain, high blood pressure, and changes in skin appearance.

The link between SCLC and Cushing's syndrome is crucial for diagnosis and management, as it can offer insights into the presence of malignancy within the lungs. Monitoring for this syndrome is an essential part of the care plan for patients with SCLC, emphasizing the significance of identifying systemic effects associated with specific types of cancer.