What histological feature is indicative of a thyroglossal tract cyst?

A thyroglossal tract cyst is a common congenital anomaly that occurs due to the incomplete closure of the thyroglossal duct, which is a remnant of the embryological development of the thyroid gland. The histological feature that is characteristic of a thyroglossal tract cyst is the presence of stratified squamous or pseudostratified squamous epithelium. This type of epithelial lining is typically found in cysts of this nature, as it reflects the embryonic origin of the tract.

The stratified squamous epithelium helps to provide protection against friction and injury, which is essential given the location of these cysts in the neck region. In some cases, the cyst may have a pseudostratified squamous lining, which is consistent with the respiratory epithelium type. The presence of this type of epithelium serves as a distinguishing feature for pathologists when diagnosing a thyroglossal duct cyst during microscopic examination.

In contrast, features such as smooth muscle tissue, keratinized epithelial lining, or simple cuboidal epithelium do not represent the typical histological characteristics associated with thyroglossal duct cysts. These features would suggest other types of structures or lesions and