What defines Cronkhite-Canada Syndrome?

Cronkhite-Canada Syndrome is defined by the presence of idiopathic multiple polyps, which are often associated with systemic symptoms such as gastrointestinal bleeding, diarrhea, and weight loss. The syndrome predominantly affects older individuals, with a higher prevalence noted among Japanese men. The term "idiopathic" indicates that the exact cause of the polyps remains unknown, distinguishing this syndrome from other conditions that have a clear genetic etiology or known inheritance patterns.

The other options do not accurately capture the nature of Cronkhite-Canada Syndrome. For instance, it is not characterized by autosomal dominant inheritance or specifically linked to juvenile polyps, which are more common in conditions like Peutz-Jeghers syndrome. Additionally, while there are multiple polyps in Cronkhite-Canada Syndrome, the lack of a known genetic cause further emphasizes the idiopathic nature of the disorder. This unique aspect makes option C the correct choice, as it highlights the syndrome's characteristics and its specific demographic prevalence.