What condition is associated with the release of thromboplastic substances into circulation?

The condition associated with the release of thromboplastic substances into circulation is Disseminated Intravascular Coagulation (DIC). DIC is a serious and complex disorder that is often triggered by various underlying conditions, such as infections, trauma, or obstetric complications.

In DIC, there is an abnormal activation of the coagulation cascade leading to the formation of blood clots throughout the small vessels in the body. This process is initiated by the release of thromboplastic substances—factors that promote blood clotting—into the bloodstream. These substances can include tissue factor, which is released from damaged tissues and can significantly contribute to this pathological state. The widespread clotting depletes platelets and clotting factors, eventually leading to bleeding complications as the body’s normal coagulation mechanisms become exhausted.

In contrast, the other choices pertain to different medical conditions that do not directly involve the widespread release of thromboplastic substances into circulation, making them unrelated to the core principle of DIC.