What characteristic lesion is associated with Erythema Multiforme?

Erythema Multiforme is characterized by target lesions, which are often described as resembling an archer's bull's eye. These lesions typically have a distinct appearance with a central dark area surrounded by a pale ring and an outer erythematous halo. This classic presentation is a key diagnostic feature of Erythema Multiforme, as it visually distinguishes the condition from other dermatological issues.

While granulomas, pearly nodules, and maculopapular rashes are associated with other conditions, they do not present the same defining features that are specific to Erythema Multiforme. Granulomas may indicate conditions such as sarcoidosis or infections, while pearly nodules are typically seen in basal cell carcinoma. A maculopapular rash is more generalized and can occur in a variety of infectious and allergic processes, making it non-specific. The unique characteristics of target lesions are thus essential for diagnosing Erythema Multiforme correctly.