Kimmelstiel-Wilson Nodules are associated with which condition?

Kimmelstiel-Wilson nodules are specifically associated with nodular glomerulosclerosis, a condition commonly seen in patients with diabetes mellitus. These nodules are acellular lesions found in the glomeruli of the kidneys and represent a pathologic change due to diabetes. They are characterized by a buildup of glycoproteins within the capillary loops, which can lead to increased intraglomerular pressure and subsequent damage to the glomeruli.

The presence of Kimmelstiel-Wilson nodules helps pathologists identify diabetic nephropathy when examining renal tissue under a microscope. Recognizing these nodules is essential for determining the underlying cause of kidney dysfunction in patients, particularly in the context of individuals with a history of diabetes.

Other conditions listed, such as focal segmental glomerulosclerosis, lupus nephritis, and chronic kidney disease, do not typically exhibit Kimmelstiel-Wilson nodules. Each of these conditions has its own distinct histopathological features and implications for kidney health, but they are not specifically associated with the nodular changes seen in diabetic nephropathy.