How is an adenoma of the nipple often diagnosed?

An adenoma of the nipple is often diagnosed by its clinical presentation and histologic features that can closely resemble Paget's disease of the nipple. This similarity arises due to overlapping characteristics of both conditions, such as the appearance of the skin and nipple discharge. Paget’s disease is associated with eczema-like changes and can present with a discharge as well, which may lead to confusion in diagnosis.

Histologically, Paget’s disease involves the presence of malignant cells in the epidermis derived from underlying breast carcinoma, while adenomas are benign lesions characterized by proliferative glandular tissue. Because of these similarities in clinical presentation and the potential for both conditions to cause similar symptoms, distinguishing between them is essential for proper diagnosis and management. This is why the recognition of adenomas as resembling Paget's disease plays a significant role in accurate diagnostic processes.

The other options provided do not accurately represent the typical diagnostic pathways for adenomas of the nipple. Mammograms are generally not the primary diagnostic tool for adenomas as they are more commonly used for evaluating masses and calcifications. Hurtle cells are not specifically associated with nipple adenomas but are more relevant in the context of certain thyroid conditions. Symptoms such as lymphadenopathy and discharge might be present, but lymphadenopathy