Familial Juvenile Nephronophthisis is likely to present with what features?

Familial Juvenile Nephronophthisis is a genetic disorder characterized primarily by kidney dysfunction that manifests in childhood. The hallmark of this condition is the presence of shrunken, cystic kidneys due to the progressive loss of nephrons and associated interstitial fibrosis. Patients typically present with symptoms such as growth retardation and signs of chronic kidney disease, which can include increased thirst and urination, as well as potential anemia related to renal failure.

This condition's age of onset and physical findings—particularly the finding of small, shrunken kidneys on imaging—make the identification accurate within the context of this question. Other symptoms and findings related to kidney function, rather than acute symptoms associated with transplant rejection or pain, are more characteristic of this disorder. Therefore, the presentation in childhood with morphological changes in the kidneys aligns well with the characteristics of Familial Juvenile Nephronophthisis.